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2022Luteolin and quercetin returned a single-digit IC50 of 4.6 µM and 6.9 µM against RNA-dependent RNA polymerase (RdRp), respectively.
F. Munafò et al, “Quercetin and luteolin are single-digit micromolar inhibitors of the SARS-CoV-2 RNA-dependent RNA polymerase
2022Mechanistic studies disclose that the reaction proceeds via a cobaloxime-promoted hydrogen atom transfer pathway to afford the product that results from cleavage of the stronger, primary allylic C–H bonds over other weaker allylic C–H bond options.
S. Wang et al, “Site-selective amination towards tertiary aliphatic allylamines
2022Successful synthesis of 264.4 mg/L L-ergothioneine using C. glutamicum
M. Kim et al, “Efficient Synthesis of Food-Derived Antioxidant l-Ergothioneine by Engineered Corynebacterium glutamicum
2022rapid identification of high-affinity macrocyclic peptides via peptide display screening followed by pharmacophore-guided de novo design of small molecules
S. Yoshida et al, “Peptide-to-Small Molecule: A Pharmacophore-Guided Small Molecule Lead Generation Strategy from High-Affinity Macrocyclic Peptides
2022Esterification of the 5′-hydroxyl moieties of GS-441524 markedly improved antiviral potency. This 5′-hydroxyl-isobutyryl prodrug, ATV006, demonstrated excellent oral bioavailability in rats and cynomolgus monkeys and exhibited potent antiviral efficacy against different SARS-CoV-2 VOCs in vitro and in three mouse models.
L. CAO et al, “The adenosine analog prodrug ATV006 is orally bioavailable and has preclinical efficacy against parental SARS-CoV-2 and variants
2022Gut bacteria deformed mouse brain cells and caused “anxiety” !
B. D. Needham et al, “A gut-derived metabolite alters brain activity and anxiety behaviour in mice
2022O-GlcNAcase inhibitor ASN90 as a multimodal drug candidate for tau and α-synuclein proteopathy
B. Permanne et al, “O-GlcNAcase Inhibitor ASN90 is a Multimodal Drug Candidate for Tau and α-Synuclein Proteinopathies
2022Modulating microglia activity through HCAR2 might be effective for preventing or treating AD.
M. Moutinho et al, “The niacin receptor HCAR2 modulates microglial response and limits disease progression in a mouse model of Alzheimer’s disease
2022Cellular senescence plays both tumour-suppressive and tumour-promoting roles depending on the cellular context.
Y. Haraoka et al, “Zebrafish imaging reveals TP53 mutation switching oncogene-induced senescence from suppressor to driver in primary tumorigenesis
2022C-type natriuretic peptide (CNP) activates intrachondrocyte Ca2+ signals to promote bone growth.
Y. Miyazaki et al, “C-type natriuretic peptide facilitates autonomic Ca2+ entry in growth plate chondrocytes for stimulating bone growth
2021Prodrug-type curcumin suppressed inflammation of the brain and spinal cord by fluctuating gut microbiota.
S. Khadka et al, “Curcumin β-D-Glucuronide Modulates an Autoimmune Model of Multiple Sclerosis with Altered Gut Microbiota in the Ileum and Feces
2021A prodrug of Pano, a lysine deacetylase inhibitor that is activated under hypoxic conditions
A. Skwarska et al, “Development and pre-clinical testing of a novel hypoxia-activated KDAC inhibitor
2021EnPGC-1, a mitochondrial activator that enhances the efficacy of PD-1 inhibitor-based cancer immunotherapy
M. Malinee et al, “Targeted epigenetic induction of mitochondrial biogenesis enhances antitumor immunity in mouse model
2021Treatment with senescent cell-depleting drugs reduced mortality and increased antiviral antibodies in aged mice infected with SARS-CoV-2-related virus.
C. D. Camell et al, “Senolytics reduce coronavirus-related mortality in old mice
2021Identification of GLS1 as essential for senescent cell survival and identification of BPTES, a small molecule that can specifically eliminate senescent cells.
Y. Johmura et al, “Senolysis by glutaminolysis inhibition ameliorates various age-associated disorders
2021Demonstrated the effect of a small molecule on familial dysautonomia
M. Ajiro et al, “Therapeutic manipulation of IKBKAP mis-splicing with a small molecule to cure familial dysautonomia
2021Discovery of a substance that strongly inhibits cancer growth and metastasis from Petasites japonicus
K. Heishima et al, “Petasin potently inhibits mitochondrial complex I–based metabolism that supports tumor growth and metastasis
2021Elevated CaMKII/Rpt-6 signaling possibly mediates the enhanced proteasome activity after SAK3 administration in the cortex and hippocampus. CaMKII/Rpt-6 activation also accounted for improved memory and cognition in α-Syn PFF-injected mice. 
J. Xuet al, “T-Type Ca2+ Enhancer SAK3 Activates CaMKII and Proteasome Activities in Lewy Body Dementia Mice Model
2021A schematic of the key cellular and biomolecular interactions between Ivermectin, host
cell, and SARS-CoV-2 in COVID-19 pathogenesis and prevention of complications have been proposed.
A. K. Zaidi et al, “The mechanisms of action of Ivermectin against SARS-CoV-2: An evidence-based clinical review article
2021Single and multiple doses of molnupiravir were evaluated in this first-in-human, phase 1, randomized, double-blind, placebo-controlled study in healthy volunteers.
W. P. Painter et al, “Human Safety, Tolerability, and Pharmacokinetics of Molnupiravir, a Novel Broad-Spectrum Oral Antiviral Agent with Activity against SARS-CoV-2
2021The antiviral effects of 5-ALA could be detected in both human and non-human cells without significant cytotoxicity. 
Y. Sakurai et al, “5-amino levulinic acid inhibits SARS-CoV-2 infection in vitro
2021Possibility of using of proline-2’-deoxymugineic acid as an iron fertilizer on alkaline soils is supported by promotion of rice growth in a calcareous soil by soil application of it.
M. Suzuki et al, “Development of a mugineic acid family phytosiderophore analog as an iron fertilizer
2021Quercetin 3,5,7,3′,4′-pentamethyl ether activated SIRT1 more effectively than resveratrol does.
M. Zhang et al, “Quercetin 3,5,7,3′,4′-pentamethyl ether from Kaempferia parviflora directly and effectively activates human SIRT1
2021Discovery of Naturido, a novel substance that improves cognitive function, from a medicinal fungus (Isaria japonica) grown on domestic silkworm (Bombyx mori)
S. Ishiguro et al, “A novel cyclic peptide (Naturido) modulates glia–neuron interactions in vitro and reverses ageing-related deficits in senescence-accelerated mice
2020About the mechanism of action of curcumin derivative, GT863
Y. Urano et al, “Curcumin Derivative GT863 Inhibits Amyloid-Beta Production via Inhibition of Protein N-Glycosylation
2020Preprint about EGCG
M. F. Khan et al, “Identification of Dietary Molecules as Therapeutic Agents to Combat COVID-19 Using Molecular Docking Studies
2020Immunomodulatory function of pterostilbene in blueberry and its mechanism of action
T. Yashiro et al, “Pterostilbene reduces colonic inflammation by suppressing dendritic cell activation and promoting regulatory T cell development
2019A Drug for Dementia from China
X. Wang et al, “Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer’s disease progression
2019Elucidated the mechanism by which insulin resistance promotes beta-amyloid accumulation in Alzheimer’s disease brains
T. Wakabayashi et al, “Differential_effects_of_diet-_and_genetically-induced brain insulin resistance on amyloid pathology in a mouse model of Alzheimer’s disease
2019Artepirin C, the main ingredient of Brazilian green propolis
R. Munakata et al, “Isolation of Artemisia capillaris membrane-bound di-prenyltransferase for phenylpropanoids and redesign of artepillin C in yeast
2019Elucidation of the biosynthetic machinery of Ascofuranone, a potential antiparasitic, and successful construction of a selective mass production system
Y. Araki et al, “Complete biosynthetic pathways of ascofuranone and ascochlorin in Acremonium egyptiacum
2018A small molecule that promotes osteoblast differentiation
Y. Fujii et al, “Bone regeneration by human dental pulp stem cells using a helioxanthin derivative and cell-sheet technology
2018A novel compound that promotes the effects of rehabilitation after brain injury
H. Abe et al, “CRMP2-binding compound, edonerpic maleate, accelerates motor function recovery from brain damage
2015New curcumin analogues with enhanced antitumor activity
A. Kohyama et al, “Structure-Activity Relationships of the Antitumor C5-Curcuminoid

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