If I find another noteworthy literature, I will update this page. If you have an interesting literature, in the case of a smartphone, please press and hold it and then click “Open” to download it.
| 2022 | Gut bacteria deformed mouse brain cells and caused “anxiety” ! B. D. Needham et al, “A gut-derived metabolite alters brain activity and anxiety behaviour in mice“ |
| 2022 | O-GlcNAcase inhibitor ASN90 as a multimodal drug candidate for tau and α-synuclein proteopathy B. Permanne et al, “O-GlcNAcase Inhibitor ASN90 is a Multimodal Drug Candidate for Tau and α-Synuclein Proteinopathies“ |
| 2022 | Modulating microglia activity through HCAR2 might be effective for preventing or treating AD. M. Moutinho et al, “The niacin receptor HCAR2 modulates microglial response and limits disease progression in a mouse model of Alzheimer’s disease“ |
| 2022 | Cellular senescence plays both tumour-suppressive and tumour-promoting roles depending on the cellular context. Y. Haraoka et al, “Zebrafish imaging reveals TP53 mutation switching oncogene-induced senescence from suppressor to driver in primary tumorigenesis“ |
| 2022 | C-type natriuretic peptide (CNP) activates intrachondrocyte Ca2+ signals to promote bone growth. Y. Miyazaki et al, “C-type natriuretic peptide facilitates autonomic Ca2+ entry in growth plate chondrocytes for stimulating bone growth“ |
| 2021 | Prodrug-type curcumin suppressed inflammation of the brain and spinal cord by fluctuating gut microbiota. S. Khadka et al, “Curcumin β-D-Glucuronide Modulates an Autoimmune Model of Multiple Sclerosis with Altered Gut Microbiota in the Ileum and Feces“ |
| 2021 | A prodrug of Pano, a lysine deacetylase inhibitor that is activated under hypoxic conditions A. Skwarska et al, “Development and pre-clinical testing of a novel hypoxia-activated KDAC inhibitor“ |
| 2021 | EnPGC-1, a mitochondrial activator that enhances the efficacy of PD-1 inhibitor-based cancer immunotherapy M. Malinee et al, “Targeted epigenetic induction of mitochondrial biogenesis enhances antitumor immunity in mouse model“ |
| 2021 | Treatment with senescent cell-depleting drugs reduced mortality and increased antiviral antibodies in aged mice infected with SARS-CoV-2-related virus. C. D. Camell et al, “Senolytics reduce coronavirus-related mortality in old mice” |
| 2021 | Identification of GLS1 as essential for senescent cell survival and identification of BPTES, a small molecule that can specifically eliminate senescent cells. Y. Johmura et al, “Senolysis by glutaminolysis inhibition ameliorates various age-associated disorders“ |
| 2021 | Demonstrated the effect of a small molecule on familial dysautonomia M. Ajiro et al, “Therapeutic manipulation of IKBKAP mis-splicing with a small molecule to cure familial dysautonomia“ |
| 2021 | Discovery of a substance that strongly inhibits cancer growth and metastasis from Petasites japonicus K. Heishima et al, “Petasin potently inhibits mitochondrial complex I–based metabolism that supports tumor growth and metastasis” |
| 2021 | Elevated CaMKII/Rpt-6 signaling possibly mediates the enhanced proteasome activity after SAK3 administration in the cortex and hippocampus. CaMKII/Rpt-6 activation also accounted for improved memory and cognition in α-Syn PFF-injected mice. J. Xuet al, “T-Type Ca2+ Enhancer SAK3 Activates CaMKII and Proteasome Activities in Lewy Body Dementia Mice Model“ |
| 2021 | A schematic of the key cellular and biomolecular interactions between Ivermectin, host cell, and SARS-CoV-2 in COVID-19 pathogenesis and prevention of complications have been proposed. A. K. Zaidi et al, “The mechanisms of action of Ivermectin against SARS-CoV-2: An evidence-based clinical review article“ |
| 2021 | Single and multiple doses of molnupiravir were evaluated in this first-in-human, phase 1, randomized, double-blind, placebo-controlled study in healthy volunteers. W. P. Painter et al, “Human Safety, Tolerability, and Pharmacokinetics of Molnupiravir, a Novel Broad-Spectrum Oral Antiviral Agent with Activity against SARS-CoV-2“ |
| 2021 | The antiviral effects of 5-ALA could be detected in both human and non-human cells without significant cytotoxicity. Y. Sakurai et al, “5-amino levulinic acid inhibits SARS-CoV-2 infection in vitro“ |
| 2021 | Possibility of using of proline-2’-deoxymugineic acid as an iron fertilizer on alkaline soils is supported by promotion of rice growth in a calcareous soil by soil application of it. M. Suzuki et al, “Development of a mugineic acid family phytosiderophore analog as an iron fertilizer“ |
| 2021 | Quercetin 3,5,7,3′,4′-pentamethyl ether activated SIRT1 more effectively than resveratrol does. M. Zhang et al, “Quercetin 3,5,7,3′,4′-pentamethyl ether from Kaempferia parviflora directly and effectively activates human SIRT1“ |
| 2021 | Discovery of Naturido, a novel substance that improves cognitive function, from a medicinal fungus (Isaria japonica) grown on domestic silkworm (Bombyx mori) S. Ishiguro et al, “A novel cyclic peptide (Naturido) modulates glia–neuron interactions in vitro and reverses ageing-related deficits in senescence-accelerated mice“ |
| 2020 | About the mechanism of action of curcumin derivative, GT863 Y. Urano et al, “Curcumin Derivative GT863 Inhibits Amyloid-Beta Production via Inhibition of Protein N-Glycosylation“ |
| 2020 | Preprint about EGCG M. F. Khan et al, “Identification of Dietary Molecules as Therapeutic Agents to Combat COVID-19 Using Molecular Docking Studies“ |
| 2020 | Immunomodulatory function of pterostilbene in blueberry and its mechanism of action T. Yashiro et al, “Pterostilbene reduces colonic inflammation by suppressing dendritic cell activation and promoting regulatory T cell development“ |
| 2019 | A Drug for Dementia from China X. Wang et al, “Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer’s disease progression“ |
| 2019 | Elucidated the mechanism by which insulin resistance promotes beta-amyloid accumulation in Alzheimer’s disease brains T. Wakabayashi et al, “Differential_effects_of_diet-_and_genetically-induced brain insulin resistance on amyloid pathology in a mouse model of Alzheimer’s disease“ |
| 2019 | Artepirin C, the ｍain ingredient of Brazilian green propolis R. Munakata et al, “Isolation of Artemisia capillaris membrane-bound di-prenyltransferase for phenylpropanoids and redesign of artepillin C in yeast“ |
| 2019 | Elucidation of the biosynthetic machinery of Ascofuranone, a potential antiparasitic, and successful construction of a selective mass production system Y. Araki et al, “Complete biosynthetic pathways of ascofuranone and ascochlorin in Acremonium egyptiacum“ |
| 2018 | A small molecule that promotes osteoblast differentiation Y. Fujii et al, “Bone regeneration by human dental pulp stem cells using a helioxanthin derivative and cell-sheet technology“ |
| 2018 | A novel compound that promotes the effects of rehabilitation after brain injury H. Abe et al, “CRMP2-binding compound, edonerpic maleate, accelerates motor function recovery from brain damage“ |
| 2015 | New curcumin analogues with enhanced antitumor activity A. Kohyama et al, “Structure-Activity Relationships of the Antitumor C5-Curcuminoid GO-Y030“ |
